FRO
                                                                                                                         71,:
                                               Lo liave an unusual- (le-ree of k-no@rled-c           i.nd      interest
                                   I-) PC ar (-'Cl                          1,                   1,
  2                                for a psy@.Iiiatri@t.   Ilis'mtin inL(-re@;tr, in '-lie @on'l field
                in c IODU' s    I                                                             u
                under cliscus3ioii are i4iibitors of Clucose combust on @"@ acetyl choline
                cstorase   3.zilii:oitorr,.
                                   5aid that tiaiaminase li@id 'o,--en surr@,,esllcd @is a f,,Iucose coinbuf-, Lion
                               -cileviel,;:   Yudki.m, Ph,-oio3-. ',Zev., 29                            Ilo,,icvEr,   it
                iiihi        2                                                      369 (1949)
                is   improbalile   tl-iat   thi.aminasc   c%fuld   be   developed   into   a   -ood   cov-:.rt   weapon.
                Sinc(-, it is aw%-Ar-          it is ineffective if f-,iv(-.n I)y molitli;  it must be injcc-bod
                or inhaled                     cl.t  that2   the   ant.   required   to   effect   a   il-rrson   ..Iith
                                                                                     0
                adequate die                   rather larce for optirium -,raliic as a ccltcr"
                AriLi-'Uliia,-nin contpoiinds  i,-cre d-'L3cusced, '-,tit they (lo not seem too pro,-,i-i        -sin7,
                as covert ,rear,,onc, bcco.lltoe of i-,Iic c-cr@i-r)ai-,-L'ui-,,c largt@ a-Tqt3. -,Ilaicii -,@ould  pro-
                't)@ibly  I)c  roriuired  to  produce  a  noticeable  ef  1'ect  on  @ii2  iiidivid-,.tal   witi-i   ali
                adcqiia-Ge  dict.
                                   meiitioned radioactive ascorbic acid.   It riay 1-1@et
                -iv6ll  by  nout  ,  in-,ec"-',-on  or  inhaled,  and  it  teilo3  to  bc  co,,icent.,:,atr.,c@t   -',n
                g2landular tis       ic.                indicit@--d that a very spiall a@-.it.  of t@,c iiiiterial
                would nro(luce     deri-,ructi6i  c@ Vr:, adrenal cor-Lc.@z.          @,ven   a   slight   dariare   to the
                adrenal   cortex   would   prodlicc,-   s,,,nTir)toms   char--ctcristic   2 of    t@cidisons    disease--
                disturbances  in  so(lj-um  ind.  @o  Lassii-im  metaboliori  -,i-id  i  i-i  Clucose  rie'u,-,tbolisii.
                Sefere Addisons disease, if not Droperly treq,-@td, wil.1 result in death.
                                     a-,re   the   names   of..Averal   individual@,   wh2o   are   active   in    luiiis
                                          fel-L thit sod,-itives siieh as 1);lrbi'llirite3 ar,3 al-oiit as rroo(i
                 -ir, anytl                is i:3 intcrrog,-Ltl.on aids. 'le tiioiirhl- alcolio.1 ii@is ,ibclit is
                            iing lie Ici2ioi                                     i         - u
                 r_,ood. Ile felt oh'oline coter--so iniiibi'uors siiould !-a in,i-est. ls- antil)oly;7.ral)h
                 aidr,.

                                              'W
                          Ile said varic)us 7@hOcIc trc@itinents are (-@.Cfec
                   -Trictil.in @zliock -is n,)t                                       "i,ro  in   ,)roclitcinr,,   an-nesia.
                                                                  'Tel
                           2                                       i   -,rc@ol 7,hoc)< is
                                                          -ictital pr,,iciicc.                     u             I)ca lu(-d
                   SICI)T)Y metlio(I 'qiicn unr-(i in ,                                                  , !,lit @tt j.,-  a
                                       2              r@liv(@n i@i onc        I-lostllc  uti'Ot'F',Ilt         re
                                                                                     sil i:,.Cac torlr proccf..,ur.Q.    Ile
                   :-,;@id "-,he Tapinesc usc(l or(.1   -;,nii,y 110 -,,rol"t                  rurrc2zit in I)sychiatrii:.
                   .pr,iclicc ditririrr the ,r-2r           a.T)parciitly sa@u.,L,@j                 L
                                                                                   @actorv                   'ilc  said  a-I'
                   terniting cti-rru-iit prodi-iccz3 nioi,e confi@,sl-.on t'ii2in r.iocz3 r(-,ct-,ific-d al-l-   '(-,r,@iatinr@
                   ciirront, -Liid a :;quarc             rcctified   cixrrcn'u   nroduce@3   tli(,-   lei:,-t    concu:3ioll.
                                                  ,7                                      A
                   T2here is a discua,,,,ion.of this in a recent issue of the P@ull,3t:Lm of @,[,ath.
                   D40ph@sics.
                                                                                 "Pyroiii(-.n".  A   dose   of   1   or   2m-
                          Polysaccliaride or       protein,  trade name,
                   gi-Tes  a  fever  of  less  t'llian  a  dc@lrc,:@,,  I)iit  -L  tcn-.L'old-inci,ciz3e  -.i-n  do5c   would
                   prodiice a def ini.to clcvation          in body teiiipera'@-,Iire.  'Altho@icilitli(, clici@iical
                   natiiro, of this2 niateriil woiil(i' iiidicate it would no-tbe offccti-ve.if r_,i-icn
                   or,-LUy,, it should be effective as an aerosol.
                                                                               Aomw2-i ieb
                                                                                              Kill
                             1                      TAKEN FR