Intensive Care Med (2021) 47:1034–1036 https://doi.org/10.1007/s00134-021-06458-3 IMAGING IN INTENSIVE CARE MEDICINE Thromboaspiration and fibrinolysis infusion for portomesenteric thrombosis after AstraZeneca COVID-19 vaccine administration Matthias Barral1*, Lionel Arrive2, Sanaa El Mouhadi‑Barnier2 and François H. Cornelis1 © 2021 Springer‑Verlag GmbH Germany, part of Springer Nature A 57-year-old woman developed portomesenteric vac- cine-associated immune thrombosis and thrombocyto- penia (VITT) 12  days after a second administration of AstraZeneca (AZ) (ChAdOx1 nCov-19, UK) COVID-19 vaccine. Abdominal computed tomography (CT) demon- strated the absence of contrast filling of the portal trunk and portal branches and bilateral kidney corticomedul- lary triangular hypodensity corresponding to a complete thrombosis of the portal trunk and branches with bilat- eral segmental kidney infarcts (Fig. 1A). Anticoagulation and corticosteroids were intro- duced. Transhepatic portography showed complete portal thrombosis and superior mesenteric vein with development of peri-gastric venous collaterals (Fig.  1B). Thromboaspiration followed by 12  h-intra-portal fibrinolysis resulted in a desobstruction of the portomes- enteric veins with a right portal branch-marginated residual thrombus, and disappearance of the venous col- laterals (Fig.  1C). A week after, abdominal CT found a complete portomesenteric veins recanalization (Fig. 1D). Very rare cases of VITT have been reported shortly after the administration of the AZ vaccine with some- times fatal outcome rising concerns about the admin- istration of such vaccine. Extensive portomesenteric vein thrombosis may require aggressive and escalating interventions. Early thromboaspiration with fibrinolysis appears safe and efficient and may be considered as an option to treat portomesenteric VITT. *Correspondence: matthias.barral@aphp.fr 1 Department of Radiology, Hôpital Tenon, Sorbonne University, 4 rue de la Chine, 75020 Paris, France Full author information is available at the end of the article 1035 Fig. 1 A 57-year-old woman developed portomesenteric vaccine-associate immune thrombosis and thrombo- cytopenia after a second administration of AstraZeneca COVID-19 vaccine. A Abdominal CT shows complete thrombosis of the portal trunk and the right portal branch (arrow), and left kidney infarcts (white stars). B Digital subtraction portography shows occlusion of the portal vein and branches, and the occlusion of the superior mes- enteric vein (arrow). Obstruction of the portomesenteric veins result in the development of gastric and splenic col- laterals (arrowheads). C Digital subtraction portography after mechanical thromboaspiration and 12 h fibrinolysis shows complete desobstruction of the portal trunk, the left portal branch and mesenteric vein (arrows) and mar- ginated residual thrombus in the right portal branch (arrowhead). This desobstruction results in the disappearance of the venous collaterals. D Coronal reformatted abdominal CT in maximum intensity projection shows complete recanalization of the portomesenteric veins 7 days after treatment 1036 Author details 1 Department of Radiology, Hôpital Tenon, Sorbonne University, 4 rue de la Chine, 75020 Paris, France. 2 Department of Radiology, Hôpital Saint‑Antoine, 75012 Paris, France. Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in pub‑ lished maps and institutional affiliations. Declarations Conflicts of interest Authors do not report any conflict of interest nor any financial interest. Received: 1 June 2021 Accepted: 9 June 2021 Published online: 16 June 2021