Natural selection done heavy lifting.The Andersen paper ’ speculation designing viral spike protein calculation bearing whether virus manipulated one two methods.The authors ’ second argument manipulation even contrived.Although living things use DNA hereditary material , number viruses use RNA , DNA ’ close chemical cousin.But RNA difficult manipulate , researchers working coronaviruses , RNA-based , first convert RNA genome DNA.They manipulate DNA version , whether adding altering genes , arrange manipulated DNA genome converted back infectious RNA.Only certain number DNA backbones described scientific literature.Anyone manipulating SARS2 virus “ would probably ” used one known backbones , Andersen group writes , since SARS2 derived , therefore manipulated .