This manufactured virus able infect cells human airway , least tested lab culture cells.The SHC014-CoV/SARS1 virus known chimera genome contains genetic material two strains virus.If SARS2 virus cooked Shi ’ lab , direct prototype would SHC014-CoV/SARS1 chimera , potential danger concerned many observers prompted intense discussion. “ If virus escaped , nobody could predict trajectory , ” said Simon Wain-Hobson , virologist Pasteur Institute Paris.Baric Shi referred obvious risks paper argued weighed benefit foreshadowing future spillovers.Scientific review panels , wrote , “ may deem similar studies building chimeric viruses based circulating strains risky pursue. ” Given various restrictions placed gain-of function ( GOF ) research , matters arrived view “ crossroads GOF research concerns ; potential prepare mitigate future outbreaks must weighed risk creating dangerous pathogens .