In developing policies moving forward , important consider value data generated studies whether types chimeric virus studies warrant investigation versus inherent risks involved. ” That statement made 2015.From hindsight 2021 , one say value gain-of-function studies preventing SARS2 epidemic zero.The risk catastrophic , indeed SARS2 virus generated gain-of-function experiment.Inside Wuhan Institute Virology.Baric developed , taught Shi , general method engineering bat coronaviruses attack species.The specific targets human cells grown cultures humanized mice.These laboratory mice , cheap ethical stand-in human subjects , genetically engineered carry human version protein called ACE2 studs surface cells line airways.Shi returned lab Wuhan Institute Virology resumed work started genetically engineering coronaviruses attack human cells .